Dna Origami Cancer Treatment
We have tested two dna origami nanostructures on three different breast cancer cell lines mda mb 231 mda mb 468 and mcf 7.
Dna origami cancer treatment. In a final demonstration they functionalized the surface of the peptoid coated dna origami with trastuzumab. Once dna hits the cancer s blood vessels the origami quickly inverts itself revealing the thrombin and sparking a cascade of events that isolates tumors. Their method has already been tested in the laboratory and has been successful against both breast cancer and leukaemia cells.
We speculated that longer virtual function time of bmepc under the protection of dna origami would be responsible for the higher pdt efficacy of bmepc loaded dna origami. The researchers used this technique to create a nanoparticle to deliver thrombin enzymes which are crucial for blood clotting to cancer cells to function as antiangiogenic agents. The thrombin delivery dna nanorobot constitutes a major advance in the application of dna nanotechnology for cancer therapy said yan.
Dna origami however can be used to deliver chemotherapy drugs in a way that can t be blocked and should have no problems killing chemotherapy resistant cancer cells. More commonly known by the brand name herceptin trastuzumab is an antibody that. In a melanoma mouse model the nanorobot not only affected.
With carrier free bmepc treatment the brightest ros fluorescence emission appeared after irradiated for 300 s wherea the bmepc loaded dna origami treatment group showed brightest emission after irradiated for 660 s figure 6. Dna nanorobots were developed from a flat rectangular dna origami sheet 90 nanometers by 60 nanometers in size and loaded with four thrombin molecules. The dna origami technique also plays a key role in accelerating the advances in this research field.
Test runs of the treatment in tumor laden. Nanopores constructed by a dna origami technique could be used to regulate the entry of therapeutic drugs into cancer cells. Also attached on the surface of the nanorobot is a dna aptamer which is similar to an antibody given its specificity and affinity towards its target.
